SEEN AND HEARD AT ARVO

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SUBJECTIVE REFRACTOR COMBINES WAVEFRONT, ARTIFICIAL INTELLIGENCE
Training to refract with Vmax Vision’s Voice Activ Subjective Refractor (VASR), which uses wavefront aberrometry and artificial intelligence, may be easier than training to refract using a phoropter but with similar refractive outcomes, a study from Southern College of Optometry suggests. After a masked investigator examined 50 healthy subjects using a standard autorefractor, SCO faculty members did subjective refinement using a standard phoropter. Meanwhile, a second-year optometry student, after two hours of training, did subjective measurements with VASR. There was no statistically significant difference in the mean equivalent sphere measurements between the phoropter and VASR. With VASR, Snellen acuity was better by more than one line in 14% of individuals, worse by more than one line in 3% of subjects, and less than one line of difference in 83% of individuals. Go to VmaxVision.com.

ARMOR STUDY ANALYZES METHICILLIN RESISTANCE
Bausch + Lomb, announced the results from the ninth consecutive year of the multicenter ARMOR (Antibiotic Resistance Monitoring in Ocular MicRoorganisms) surveillance study. In the nine-year trend analysis, researchers reported that resistance in Staphylococcus aureus infections declined from 39% to 14%, while more than half the cases of coagulase-negative staphylococci (CoNS) demonstrated continued methicillin resistance.
Further analysis showed decreased resistance among S. aureus to azithromycin (62% to 52%), ciprofloxacin (39% to 16%), tobramycin (24% to 6%), and chloramphenicol (6.6% to 4.4%), and among CoNS to ciprofloxacin (46% to 22%). As in previous years, a high proportion of methicillin-resistant staphylococci demonstrated multidrug resistance (three or more antibiotic classes), although none were vancomycin-resistant. Go to Bausch.com.

UV BLOCKER DOUBLES AS ANTIOXIDANT
Norbloc, the ultraviolet blocker in Johnson & Johnson Vision’s ACUVUE Brand Contact Lenses, behaves as an antioxidant and provides a protective effect to a tear component that can be taken into the lens during wear, two studies showed. In one study, researchers compared the antioxidant capacity of Norbloc to 10 known antioxidant compounds using Oxygen Radical Absorbance Capacity (ORAC) and found that the ORAC score was four times higher than vitamin E and was significantly higher than nine out of the 10 antioxidants tested.
In a second study, researchers compared silicone hydrogel lenses formulated with and without Norbloc using an experimental lipid model to determine how much a tear film lipid absorbed into the lenses oxidizes. After exposure to different doses of hydrogen peroxide and UV light, lenses that did not contain Norbloc showed statistically higher amounts of oxidative degradants compared to the lenses that did contain Norbloc. Go to JJVision.com.

EXTENDED-RELEASE TRAVOPROST OFFERS EXTENDED IOP CONTROL
Preclinical study results showed that LayerBio’s intracameral extended-release formulation of travoprost lowers intraocular pressure to therapeutic levels for longer than six months. LayerBio’s extended-release travoprost formulation is based on its PolyNet technology, a proprietary network polymer-based delivery platform. The platform enables tunable control of drug release from a biocompatible, bio-erodible polymer system with a variety of classes of medications for glaucoma and other ophthalmic indications. Go to LayerBio.com.

CORE CELEBRATES 30 YEARS OF OCULAR RESEARCH
The Centre for Ocular Research & Education (CORE) used ARVO 2018 to celebrate its 30th anniversary. CORE, formerly known as the Centre for Contact Lens Research, was established May 1, 1988, at the University of Waterloo’s School of Optometry & Vision Science. During the next three decades, the organization evolved from a three-person operation into a hub of basic and applied research, collaborating with sponsors, agencies and academia on advanced biosciences, clinical research and education. Now, its approximately 50-person team serves a range of ophthalmic sectors, including medical devices, ocular pharmaceuticals, digital technology and others, with a focus on the anterior segment. Go to CORE.UWaterloo.ca.

A study on the technology presented at ARVO 2018 evaluated different pathologies using the equipment and comparing it to standalone OCT. Features of drusen, atrophy, pigment epithelial detachment, cystoid macular edema, ellipsoid zone disruption, subretinal drusenoid deposits, nerve fiber layer thinning, vitreo-macular traction, and epiretinal membrane were identified similarly on both devices. Using the ultra-widefield OCT, additional lesions such as drusen and hemorrhages could be observed beyond the OCT scanning field.[1]
1. Gresores NJ, Singer M, Cairns AM, et al. Evaluation of a combined ultra-wide field SLO with SD OCT. ARVO Abstract 664 -C0222.
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