The AdenoPlus by Nicox is a point-of care test that helps more accurately identify the underlying etiology of acute red eye.

Nicox’s AdenoPlus helps practictioners make the correct red eye diagnosis.

Would it to surprise you to know that eyecare professionals (ECPs) make a correct diagnosis of the etiology of the red eye only about 50% of the time?  Fortunately, the AdenoPlus™ by Nicox is a point-of-care test that helps more accurately identify the underlying etiology of acute red eye problems presenting to our practices.

Understanding the etiology and pathogenesis of the various causes of the presenting red eye has been the historical means of diagnosing the underlying cause. It is estimated that 90% of viral conjunctivitis is caused by adenovirus. But as many of us ECPs know, it is often misdiagnosed due to the overlapping presentation of signs and symptoms among the major subtypes.

Misdiagnosis represents a major problem, as adenovirus is highly contagious and associated with significant morbidity, including decreased visual acuity, light sensitivity, chronic excessive tear production, visual loss, and presence of subepithelial infiltrates. Being able to identify the cause of the presenting conjunctivitis provides us with the opportunity to better target therapeutic regimens to match the reason for the cause.

The AdenoPlus is a relatively rapid assessment that is utilized in the office. All of the supplies needed to perform the test are present in an individually packaged box. The sample collector is dabbed and dragged along six to eight locations on the lower palpebral conjunctiva of the affected eye. It is then snapped into the test cassette where the tip is dipped into a buffered vial for 20 seconds, with a cap on top. Once the test cassette has been removed from the buffered vial, the practitioner needs to wait 10 minutes to read the results.


“Many red eyes share the same signs and symptoms. AdenoPlus increases my confidence in the proper diagnosis and treatment.”

—Scott B. Han, OD,
The Eye Associates,
West Bradenton, FL

“We are now enforcing a red eye protocol. All patients presenting with a red eye are confined to a single room and offered testing with the AdenoPlus. This facilitates proper diagnosis and limits potential spread of infection. The result is significantly improved care for this very common problem.

—Art Epstein, OD,
Phoenix Eyecare, PLLC,
Phoenix, AZ

Test results are read by observing the lines that show up in the viewing window of the test cassette. The control line shows up as a blue line in the test cassette window. This shows whether you have obtained an adequate sample to be analyzed. If a second red line appears, it means adenovirus exists in the collected sample. However, it is important to note that if you perform the test and the control line does not appear, an inadequate amount of sample has been collected and the test needs to be performed again.

One of the significant benefits to the test is that there is not a significant capital investment that is required to incorporate it into your practice. The tests are individually packaged and there are 10 per box. Additionally, you can bill for the test utilizing CPT code 87809.  In order to utilize this code, you will need to apply for a Clinical Laboratory Improvement Amendments (CLIA) waiver.


The test is an effortless tool that takes less than two minutes to complete—a helpful remedy for a busy office. The easy four-step process can be performed by either an OD or paraoptometric and helps tremendously in gathering significant information to help differentiate the cause of the acute red eye.

In our offices, the paraoptometric will perform the test on patients presenting to the office with a red eye without an obvious etiology.  Ultimately, this gives the clinician valuable information regarding the cause of the presenting red eye to more strategically implement a successful therapeutic approach.

We encounter patients in our practices with red eyes on a regular basis. Helping them get the right treatment sooner rather than later makes all the difference.

Mile Brujic practices at Premier Vision Group in Bowling Green, OH; David Kading practices at Specialty Eyecare Group with locations in Seattle and Kirkland, WA


Nicox • 800-929-1431 •


Leave A Reply